Definitely always good to experiment!
I have for a LONG time now used a mixed set on most of my strat-style guitars, meaning I have a 50 (or50)-40-30 or so lower end and 009, 11, 17 high end.
It gives me really snappy chording and a firm bass end just like a normal .11 set but still allows for lively vibratos and easy bending. I played a .11 set for a decade but when I started playing more leads it got annoyingly hard to play them. I like to bend all the strings pretty much, even when playing rhythm I do a lot of small bends for effect all the time, but on lower strings it can be done pulling downwards and that works even with the heaviest gauges - but that top E is really hard to bend especially on 1,5 step bends, and even harder it is to bend it and THEN apply vibrato accurately to the bent note, which is my favorite - with an .11 it can still be rather easily bent at least a full note, but then trying to keep it bent and applying vibrato and keeping the overall tune correct...well you need a niner basically to do that unless you have superhuman finger strength. I try to do it without supporting my hand on the neck while bending too, and then shake my entire hand or body at the top of the bend, kinda hanging the whole guitar on the finger doing the bend - can you guess Angus Young is my guitar hero ;-)
BUT I also have one guitar strung with regular 10's and one with ultralite 009's. I like having different touches on guitars. Although, due to shorter scale my Flying-V with 10's feels pretty similar to play as the strats with 009 top end anyways.
I'm just in the process of figuring out what can I do to make the floyd-guitar with them 009'rs sound a tad warmer and thicker, as it IS so clearly thinner-sounding than my other axes - no wonder with an ultralight dinky body, thin neck and a floyd

but maybe I can install an onboard EQ/bottom boost or also I'm thinking of trying a Blackout there and see if that yields more low end than the EMG85, which I doubt, though.